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GLP-1 rec agonists have evolved over the past 20+ years as game-changers for type 2 diabetes to highly effective medications for the treatment of obesity by targeting the neurometabolic pathophysiology of obesity
This butyrate, in turn, stimulates GLP-1 secretion by activating specific receptors on the intestinal L-cells that produce it
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Patients should intentionally hydrate , aiming for adequate daily fluid intake consistent with national hydration guidelines , adjusted for body size and activity.⁴ ⚠️ Key point: Fiber without adequate fluid intake can worsen constipation by increasing stool bulk without improving passage
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