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Specifically: Monitor routinely muscle strength and function amino-acid profiles short half-life proteins emerging resilience markers (e.g., GDF-15) Mitigate proactively adequate protein intake (≥1.2–1.5 g/kg/day) resistance or mixed exercise consider adjuncts that preserve muscle mass identify early biomarker patterns of ERM These steps do not contradict the use of GLP-1RAs—they optimize it
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Note: MNF = Manufacturer While operational excellence is essential to bringing oral GLP-1s to scale, commercial success will hinge on a distinct and equally demanding set of commercial and medical capabilities, with market education playing a pivotal role
