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The following symptoms require prompt medical evaluation rather than being treated as routine gastrointestinal discomfort: Severe, persistent upper abdominal pain that doesn't respond to position changes or over-the-counter remedies Pain radiating to the back — this classic pancreatitis presentation distinguishes it from routine GI discomfort Pain accompanied by persistent vomiting that prevents keeping any fluids down Fever combined with abdominal pain — suggests an inflammatory or infectious process Published guidelines from the European Association for the Study of Diabetes recommend that GLP-1 receptor agonist treatment should be stopped immediately when pancreatitis is suspected, pending full clinical evaluation