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Specifically, at concentrations of 100 nM and 1,000 nM, GLP-1R agonist 2 significantly enhances 10 mM glucose-induced insulin secretion, similar to GLP-1, and this effect is abolished in islets from GLP-1 receptor knockout mice [2]

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5 The hippocampus plays a central role in memory and emotion, and a distinctive feature of this region is its ability to generate new neurons throughout life within the dentate gyrus