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It is tempting to speculate that treatment of GLP-1 RAs might be combined with drugs targeting calcium clock dynamics or intracellular calcium levels, such as calcium channel blockers, or other downstream effectors, to prevent heart rate increases in patients receiving GLP-1 RAs where this may be considered beneficial
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Bibliography searches Before experimental evaluation, an exhaustive bibliographic search was conducted to assess whether the computationally prioritized compounds had been previously reported or associated with obesity, metabolic disorders, or incretin-related pathways
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