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However, cohort characteristics again suggest a relatively mild disease population, with only 3.0% of patients having perianal CD, 0.8% with intestinal fistulas, and baseline advanced therapy use in 32% of CD and 19.6% of UC patients in the GLP-1RA group

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Shanzhiside methyl ester, the main active component of Lamiophlomis rotata, also significantly reduced pain sensitivity in neuropathic rats over time without leading to tolerance [102]