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Ozempic targets only GLP-1 receptors, while Mounjaro activates both GLP-1 and GIP receptors, potentially explaining its edge in A1C reduction and weight loss results
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Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]
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