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Targeting enteral endocrinal L-cells with dietary carbohydrates, by increasing the availability of miglitol in the intestinal lumen, leads to multi-fold enhancement of plasma glucagon-like peptide-1 levels in non-diabetic canines

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It is mainly produced by enteroendocrine L-cells, which are distributed throughout the gastrointestinal tract, with increasing density from the proximal jejunum to the colon (16)