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Some people lose even more weight – up to 20% of their starting weight with medications like tirzepatide (Zepbound)
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Therefore, given the potential for increased risk of fat mass gain, persistent muscle loss, and declining physical capacity with weight cycling, coupled with evidence that the prevalence of sarcopenic obesity is estimated to be ∼20% in obese treatment-seeking adults [15], it is possible voluntary weight loss followed by involuntary regain may increase (or further exacerbate) the risk of sarcopenia and sarcopenic obesity, particularly in older adults
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