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Our experiment aims to clarify the mechanism of berberine promoting the secretion of GLP-1 in intestinal L cell and islet α cell, activating GLP-1R and its downstream molecules through endocrine and paracrine ways, thus improving the function of islet β cell and treating T2DM
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Additionally, injection-site reactions at the subcutaneous administration point might cause localized itching or sensitivity, though this usually resolves within days after injection
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