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Because of their opposite functions on food intake and metabolic targets (Engelstoft & Schwartz, 2016), both hormones have gained traction as pharmacological targets for treatment of metabolic (i.e., obesity and type 2 diabetes (T2D)) and eating disorders (Atalayer et al., 2013

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Even with personal trainers, private chefs, and full resources (as Oprah Winfrey has shared), sustainable weight loss can be challenging