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More likely, within the very high risk (prior CV event) T2DM population of EMPA REG OUTCOME, there was an even higher risk subpopulation (i.e., with severe LV dysfunction, myocardial ischemia, ventricular irritability) who was at imminent risk of experiencing a CV event and the simultaneous, acute reduction in both preload and after load reduced myocardial oxygen consumption, decreased myocardial stretch and ventricular irritability, and enhanced myocardial energetics, thereby rapidly reducing their CV mortality risk
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