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Keywords: Type 2 diabetes mellitus, GLP-1 receptor agonist, SGLT2i inhibitor, Glycemic control, Cardiovascular disease PATHOPHYSIOLOGY OF TYPE 2 DIABETES MELLITUS (T2DM) The Triumvirate In 1987 our understanding of the pathophysiology of type 2 diabetes mellitus (T2DM) was relatively simple and referred to as the TRIUMVIRATE (1)