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Subsequent hexamethonium administration immediately led to a robust and stable increase in heart rate ( Figure 3D ) and a modest but brief increase in blood pressure (see Supplementary material online, Figure S3B )
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Across these 22 RCTs, interventions ranged from short-term (8 weeks) to long-term (up to 72 weeks), as did study populations, including individuals with obesity, T2D, prediabetes and NAFLD/MASLD, with sample sizes from 15 to 371 participants
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