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Truncation of the first two residues of GLP-1, to yield GLP-1(9–36)amide, resulted in reduced affinity and a substantial loss of efficacy [17], and hence the residues in the receptor interacting with the extreme N-terminus of the agonist would be expected to be critical for receptor activation
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WHO guideline on the use of glucagon-like peptide-1 (GLP-1) therapies for the treatment of obesity in adults
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